Sodium hydrogen carbonate is widely used in pharmaceutical formulations, for pH adjustment, as buffering agent, as antacid or in dialysis solutions. In effervescent tablets in conjunction with citric or tartaric acid it releases carbon dioxide, which enhances the dispersion and dissolution of medication.
Depending on those different applications in ethical medicines or OTC products BICAR® CODEX can be used as an excipient or as a component in a medical device.
BICAR® CODEX is the right product when you use a pharmaceutical Sodium Hydrogen Carbonate as excipient, in Hemodialysis, or as high purity material for chemical synthesis.
BICAR® Codex fulfills the requirements of the European Pharmacopoeia 7th edition and of the American Pharmacopoeia USP 33.
The following restriction has to be taken into account: BICAR® CODEX is not authorized to be used as API, in parenteral formulations or in peritoneal dialysis. Those applications demand more severe and specific requirements, which are not fulfilled by BICAR® CODEX.
Chemical and physical properties
BICAR® CODEX consists of white crystals or of white, granular or crystalline powder. It is soluble in water and decomposes during heating in the dry state or in solution to sodium carbonate under evolution of CO2 gas.
2 NaHCO3 --> CO2 + H2O + Na2CO3
CO2 gas is also formed during reaction with acids:
NaHCO3 + HCl --> NaCl + CO2 + H2O
NaHCO3 + CH3CHOHCOOH --> CH3CHOHCOONa + CO2 + H2O
The pH value of Sodium Hydrogen Carbonate in an aqueous 1 % solution is about 8.4.
BICAR® CODEX is available in different particle size distributions.
Please contact us to know whether we have suitable grade for your application.